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I disse tilfellene blir cannabinoider ofte brukt i tillegg til annen medisinsk behandling, og ikke alene. De blir typisk brukt etter at en pasient ikke har hatt effekt av anbefalt behandling for disse lidelsene.Det er uvisst hvordan bruk av tobakk og cannabis i kombinasjon påvirker risikoen for kreft og lungesykdom sammenliknet med tobakksbruk ale
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